The San Francisco 49ers need a victory to reach .500, and so far things are looking up. They have jumped out to a quick 7 to nothing lead against the Buffalo Bills.

The 49ers have been relying on WR Brandon Aiyuk, who has snatched one receiving TD, and QB Nick Mullens, who has passed for one TD and 30 yards on four attempts. Buffalo has been led by WR Cole Beasley, who so far has caught three passes for 69 yards.

This is the first time Buffalo has been down going into the second quarter in the past five games.

Who’s Playing
Buffalo @ San Francisco

Current Records: Buffalo 8-3; San Francisco 5-6

What to Know
After two games on the road, the San Francisco 49ers are heading back home. They will take on the Buffalo Bills at 8:15 p.m. ET on Monday at State Farm Stadium. San Francisco will be seeking to avenge the 45-16 loss they suffered the last time these two teams played Oct. 16 of 2016.

It was a close one, but last week the 49ers sidestepped the Los Angeles Rams for a 23-20 victory. No one had a standout game offensively for San Francisco, but they got scores from DE Kerry Hyder, RB Raheem Mostert, and DT Javon Kinlaw.

San Francisco’s defense was the real showstopper, as it collected two interceptions and two fumbles. The picks came courtesy of CB Richard Sherman and Kinlaw.

Meanwhile, Buffalo had a touchdown and change to spare in a 27-17 win over the Los Angeles Chargers last week. Like San Francisco, the Bills didn’t have any clear offensive standouts, but they got scores from WR Cole Beasley, TE Dawson Knox, and WR Gabriel Davis. QB Josh Allen ended up with a passer rating of 135.40.

This next game is expected to be close, with the 49ers going off at just a 1.5-point favorite. Their home turf has been no bettor’s paradise, though, as they’ve failed to beat the spread in four of their five home games.

Their wins bumped San Francisco to 5-6 and Buffalo to 8-3. We’ll see which team can carry over their success and which team inevitably falls when San Francisco and Buffalo clash.

How To Watch
When: Monday at 8:15 p.m. ET
Where: State Farm Stadium — Glendale, Arizona
TV: ESPN
Online streaming: fuboTV (Try for free. Regional restrictions may apply.)
Follow: CBS Sports App
Ticket Cost: $95.00
Odds
The 49ers are a slight 1.5-point favorite against the Bills, according to the latest NFL odds.

The line on this game has moved quite a bit since it opened, as it started out with the Bills as a 3-point favorite.

Over/Under: -110

See NFL picks for every single game, including this one, from SportsLine’s advanced computer model. Get picks now.

Series History
Buffalo won the only game these two teams have played in the last six years.

Oct 16, 2016 – Buffalo 45 vs. San Francisco 16
Top Projected Fantasy Players
Raheem Mostert: 9.8 points
Stefon Diggs: 8.61 points
Deebo Samuel: 8.21 points
Live updates (74)
Beautifully-designed play for the TD to Knox. They just ran a sweep to the left for the first down, so they faked the same run and slipped Knox across the formation with two blockers out in front.

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